ABSTRACT
To determine the frequency and severity of noise induced hearing loss [NIHL] and its audiometric configurations among Pakistan Army Aviation personnel. Cross sectional descriptive study. From June 2009 to May 2010 at ENT department of CMH Gujranwala. A total of 100 individuals who were exposed to turbo-propeller aircraft's engine noise for more than two years were recruited and assessed for hearing impairment. All the subjects were evaluated through detailed history and clinical examination. Pure tone audiometry was carried out and pathological audiograms with sensorineural hearing loss were segregated. Hearing thresholds and audiometric configurations were recorded. Out of the 100 subjects enrolled NIHL was found in 32% individuals. Among them, 20 [62.5%] patients suffered from bilateral pathology. It was mild in 13 [40.62%], moderate in 14 [43.75], and severe in 5 [15.62%] cases. The most common audiometric configuration was the notched audiogram with a dip at 4 kHz occurring in 14 patients followed by slope configuration found in 13 patients. Aviation workers are exposed to exceptionally intense noise which can render them physically and socially handicapped at times. The intricate nature of such impact entails a prompt recognition and adoption of necessary prophylactic measures to minimize the risk of developing a rather irreversible sensory handicap
ABSTRACT
The study was planned with an aim to identify the toxicity of streptomycin in the treatment of Tuberculosis. It's early an easy detection, establishment of existing damage without the use of sophisticated, costly and time consuming methods and also to assess the existing popular modalities of treatment. This prospective study was carried out in the Chest Ward and OPD JPMC Karachi and duration of twelve weeks. Patients were selected from chest ward and OPD of JPMC. Prospective randomized study of adverse effects of Streptomycin in the treatment of tuberculosis was done. It showed that like other antituberculous drug the streptomycin must be careful to use in combination therapy in the treatment of tuberculosis. The major side effects were those giving rise to serious health hazards, and required discontinuation of the drug. Minor side effects caused relatively little discomfort and often responded to symptomatic or simple treatment but occasionally persisted for the entire duration of drug treatment. In fact tuberculosis drugs are relatively toxic and side effects are not uncommon but most of them do not warrant drug withdrawal